Ranpirnase (Onconase) is a ribonuclease agent that degrades any mRNA, by breaking down in cells; it’s a natural derivative of oocytes of Rana pipiens, a Leopard northern frog, and it’s 100% free of side effects or risky consequences on human health. PRN100 is an anti-PrPC monoclonal antibody which counteracts prions harmful action, such as neurodegenerative diseases. Ranpirnase + PRN100 combo prevents all negative effects to which mRNA leads.

Ribonuclease is a large class of agents that allow to degrading any RNA, by breaking down each any in cells, than eliminating all residues.

In the picture below you can see all the differences between a various RNase agents, divided by its relative class.

Ranpirnase is even called Onconase, and contains the active agent amphinase, from RNase II class, while among the other classes, the main one are RNase I and III.

Anti-PrPC in Prions Immunotherapeutics

Codon bias usage is a technique deployed into the sequencing art, to synthetize the modified mRNA; it’s developed by choosing all the frequent codons, instead of rare codons, editing the genetic sequence of mRNA to obtain a quicker proteins production and to increase expression. Since any amino acid is coded by a certain number of nucleotides, which are all synonims among them, Bioengineers modifying all the three based groups (triplets), apply substitution with frequent CG usage, especially for the letter in the third position (Wobble position), because the elements producted would be the same. This is a bio law, but not every time elements are identical to the designed Spike protein, in facts, wrong codon usage has high influence on ribosomes, that operating follow the instructions to create proteins, lead to a loops, mismatching regions and premature stop codon, with truncated or malformed proteins, that will take outside the cytoplasm, into the body.

In addition, wrong codon usage leads to alteration of ribosomal frameshifting +1, i.e. ribosomes easily shift and switch,  with a negative effects on the general sequence stability, even linked to the tRNA balance, knowing that tRNA is the master code controller, which examinates any product by ribosomal mechanism, so if tRNA is compromised, all the sequence could be a source of unknowed proteins, with ignote functions and effects.

Prions and amyloids are misfolded proteins, generated due to the possible errors in reading, translating or while ribosomes execute instructions present in the mRNA, building proteins; this could lead to a pletora of consequences on the human health, and PRN100 monoclonal antibody is a ICSM18 derivative, a mouse antibody, that in vitro had revealed an usefull agent to counteract prion diseases and amyloidosis negative action on the organism which has received a mRNA inoculation. PrPᴰᶦˢ indicates all prions derivated diseases and they are halted from anti-PrPC, such as PRN100.
In vivo, PRN100 has tested only one time, by Cambridge University in Massachusset, with encouraging results in prevent prions disease and to notable slowing down the PrPᴰᶦˢ progression.

mRNA Platform Problems

The new mRNA vaccines platform has been shown to reveal many side effects, even of critical severity. Let's look at some of them:

SNC and Neurological Disorders:
Neurodegeneration, dementia, encephalopathy, CJD-like sympthoms, Bell’s Palsy, epilepsy and seizures, Alzheimer-like sympthoms, AmyotrophicLateral Sclerosis (ALS), alterations in perceptionand paresthesias, psychosis;

Cardivascular System:
Abnormalities of cardiac electrical conduction, with onset of ventricular fibrillation that leading to cardiac arrest and sudden death, stroke-like events, ischemia, cerebrovascular accidents, thrombosis, blood clots;

Lung Apparatus:
Occurence of pneumonia outbreakings, Sars-CoV-2 like sympthoms, inflammation in bronchi, pleura, pulmonary edema and pulmonary thrombosis;

Autoimmune Diseases:
All manifestations of attacking by the organism itself against the glands, organs, apparatuses such as: Multiple Sclerosis (MS), Crohn's disease, uclerative colitis, psoriasis, rheumatoid arthritis (RA), lupus;

Internal Disorders:
Multiorgan failure, Multisystemic inflammation, cystic fibrosis, drug resistance (especially on antibiotics);

Oncogenesis, Cancer cells:
Sudden malignant cells onset, various tumor kinds outcoming, metastasis, reignition of malignant cells production already considered extinct;

OnCoviRNase® against mRNA prions-like effects

OnCoviRNase© is the combination of two elements joined together, and it would form an engineered compound called Immunornase, capable of preventing the appearance of effects due to the production of unintended proteins by preventing their generation at the incoming and, at the same time, counteracting any iatrogenically symptomatic activity.

Only the highest titration active ingredients are used in the final product, extracted and derived from totally safe sources of natural origin, according to the highest food and health safety standards.

RawBullet® is a business actives in Biotechnology and Bioengineering science applied to Medicine and Pharmacology from 2018 and based in Lesa (NO), Italy.

The original paper PDF is visible here: