BNT162b2 Vaccine: Possible Codons Misreading, Errors in Protein Synthesis and Alternative Splicing's Anomalies by Dr. Kira Smith MD, MSc in Experimental Medicine and Forensic Pathology is an article published on International Journal of Antivirals and Antiretrovirals by Longdom Publisher on 05 Feb. 2021, then present on ResearchGate, Authorea, Academia, which highlights the points in the genetic sequence of the mRNA contained in the Pfizer vaccine that, as a result of the codon optimization process, may create problems in the reading, translation and execution of the instructions contained therein.
One of the most important factors is the introduction of a methylated, synthetic form of Pseudouridine in place of Uracyl, which is notorious in the scientific literature for causing problems in the translation of the genetic sequence, with the possibility of errors in the stop codon and more.
Another important aspect is the replacement of all letters in the third position, for each triplet in the sequence, with a C or a G, this results in increased speed of protein production and protein expression, but performing the task quickly can result in errors and production of proteins other than the designated S Spike, which become prions, i.e., elements harmful to the organism.
The last area of concern is the possibility of errors occurring in the Alternative Splicing process during the partitioning of the premRNA injected with the vaccine, which is broken down into mature mRNAs; while in nature these errors are quite rare, in the presence of nonbiological, but artificial and engineered material, it is possible that the probability of errors increases disproportionately and the outcomes, as evidenced by clinical experience, are of extreme severity, causing critical pathological situations.
The concretely critical outcomes that can occur are as follows:
Cardiovascular system: alterations in cardiac electrical conduction and abnormal beating with tachycardia, arrhythmia, and atrial or ventricular fibrillation, with sudden death; stroke-like events and ischemia, infarction, thrombi, vessel occlusion, myocarditis and pericarditis, inflammation of vessels;
Respiratory system: pneumonia, bronchopneumonia, suspicious foci in bronchi, pulmonary edema, pleurisy, various inflammations;
Neurological apparatus: neurodegeneration, encephalopathy, encephalitis, onset of Parkinson's or Alzheimer's-like symptoms, tremors, blurred vision, diffuse tingling and paresthesias, neuropathic pain, paralysis or hemiparesis, Creutzfeldt-Jakob disease and similar pathological expressions, impairment of memory and cognitive abilities, learning, language and orientation in space or alterations in temporal perception;
Internal Medicine: fat in the liver,hepatitis, alterations in AST, ALT, GOT, GGT and other values concerning cholesterol and triglycerides, increased production of catecholamines and cortisol, adrenal gland stress, imbalances in blood glucose management and glucose breakdown, in liberated energy production, oxygen transport, cystic fibrosis, ovarian cysts increased red blood cells and C-reactive protein, as a cause of widespread inflammation, up to multiorgan dysfunction syndrome.
This is the abstract:
BNT162b2 vaccine against Covid-19 is composed of an RNA having 4284 nucleotides, divided into 6 sections, which bring the information to create a factory of S Spike proteins, the ones used by Sars-CoV-2 (Covid-19) to infect the host. After that, these proteins are directed outside the cell, triggering the immune reaction and antibody production. The problem is the heavy alteration of the mRNA: Uracil is replaced to fool the immune system with Ψ (Pseudouridine); the letters of all codon triplets are replaced by a C or a G, to extremely increase the speed of protein synthesis; replacement of some amino acids with Proline; addition of a sequence (3'-UTR) with unknown alteration. These impairments could cause strong doubts about the presence of codon usage errors. An eventual mistranslation has consequences on the pathophysiology of a variety of diseases. In addition, mRNA injected is a pre-mRNA, which can lead to the multiple mature mRNAs; these are alternative splicing anomalies, direct source of serious long-term harm on the human health. In essence, what will be created may not be identical with protein S Spike: just an error in translational decoding, codons misreading, production of different amino acids, then proteins, to cause serious long-term damage to human health, despite the DNA is not modified, being instead in the cell nucleus and not in the cytoplasm, where the modified mRNA arrives. However, in this case, the correlation between speed of synthesis and protein expression with synthesis errors, as well as the mechanism that could affect the translation of the sequence remain obscure, many trials have not yet been performed.
International Journal of Antivirals Antiretrovirals by Longdom
DOI: 10.35248/1948-5964.21.13.210
Dr. Kira Smith
MD, MSc in Experimental Medicine and Forensic Pathology